Special issue Frontiers in Neuroscience : “Application of Proteomics, Metabolomics, or Transcriptomics in Nerve Injury Repair”

About this Research Topic

Transcriptomics, metabolomics, and proteomics form different layers of the so-called omics cascade, each of which characterizes a biosystem or an organism at different biomolecular levels. The rapid development of microarray, RNA sequencing, and mass spectrometry (MS) technologies have enabled relatively high-throughput analysis of the transcriptome, proteome, and metabolomes, which has provided useful tools for acquiring information for molecular profiling, finding new biomarkers, characterizing complex biochemical systems, and clarifying the pathophysiological processes in various diseases. Multi-omics analysis has also been applied to biomarker discovery and functional analysis. This Research Topic focuses on the application of transcriptomics, proteomics, metabolomics, or multi-omics in the mechanism of nerve injury repair or finding a novel biomarker of early diagnosis of nerve injury, aiming to understand the mechanism of nerve injury repair better, serving as a forum for the discussion of the mechanism of nerve injury and the discovery of novel physiological and pathological molecules.

This research topic aims to find new biomarkers of nerve injury, which can be seen as indicators of treatment effect, explore novel methods, tools and strategies to promote nerve injury repair, and elucidate the potential pathophysiological mechanism of nerve injury via proteomics, metabolomics, or transcriptomics. What’s more, we also would like to investigate the novel protein molecule which can be seen as a new target for drug design in nerve injury. Advances in microarray, RNA sequencing, and MS technologies, transcriptomics, proteomics, metabolomics or multi-omics shed new light on the nerve injury research, drug targets research, and finding the biomarker of nerve injury.

All Original Research and Review ariticles that focus on, but are not limited to, the topics mentioned below are welcome:
• Novel methods, tools, and strategies of detecting the biomarker of nerve injury via transcriptomics, proteomics, metabolomics, or multi-omics.
• Finding a novel protein molecule which can be applied as a target for new drug design in nerve injury via transcriptomics, proteomics, metabolomics, or multi-omics.
• Elucidating the potential pathophysiological mechanism of nerve injury via transcriptomics, proteomics, metabolomics, or multi-omics.
• Researching the influence factors of nerve injury repair via transcriptomics, proteomics, metabolomics, or multi-omics.
• Potential strategies or mechanisms of neuroregeneration via transcriptomics, proteomics, metabolomics, or multi-omics.

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